[²H₂₆]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus

• Christian A. Citron and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2013, 9, 2841–2845, doi:10.3762/bjoc.9.319

• kinetic isotope effects [18] may alter product distributions in branching biosynthetic pathways, which can be useful for their mechanistic interpretation [19]. At high deuterium concentrations such kinetic isotope effects slow down all metabolic processes, and consequently only very few reports on the

• [15], allowing for a detailed interpretation of the mass spectrum of a deuterated analyte. A drawback is that high incorporation rates are required to investigate the site of incorporation by 1H NMR spectroscopy, but 2H NMR spectroscopy offers a suitable alternative [16][17]. Furthermore, deuterium

Kinetics and mechanism of the anilinolysis of aryl phenyl isothiocyanophosphates in acetonitrile

• Hasi Rani Barai and
• Hai Whang Lee

Beilstein J. Org. Chem. 2013, 9, 615–620, doi:10.3762/bjoc.9.68

• and with rate-limiting bond formation for less basic anilines is proposed based on the positive and negative ρXY values, respectively. The deuterium kinetic isotope effects involving deuterated anilines (XC6H4ND2) showed primary normal and secondary inverse DKIEs for more basic and less basic anilines

• . Keywords: anilinolysis; cross-interaction constant; deuterium kinetic isotope effects; phosphoryl transfer reaction; reactive intermediates; Y-aryl phenyl isothiocyanophosphates; Introduction The nucleophilic substitution reactions of tetracoordinate phosphorus have been studied extensively

• ). The kinetic results of the present work are discussed based on the selectivity parameters and deuterium kinetic isotope effects (DKIEs). The aim of this work is to gain further information on the substituent effects, DKIEs and mechanism of the phosphoryl transfer reactions. Results and Discussion